Ibuprofen 200mg
Reduces pain, fever AND inflammation.
Estimated: $8–12 per pack View Product
500mg tablets, 100-count bottle
Order FDA-Approved Acetaminophen 500mg — Gentle, Reliable Pain & Fever Relief
500mg tablets, 100-count bottle
Acetaminophen (also known as paracetamol or APAP) is one of the most widely used OTC pain relievers and fever reducers in the United States. It is the active ingredient in Tylenol and hundreds of other branded and generic products. Unlike NSAIDs such as ibuprofen, acetaminophen does not reduce inflammation, but it is gentler on the stomach and suitable for a broader range of patients.
Acetaminophen 500mg is indicated for the relief of mild to moderate headaches, back pain, muscle aches, arthritis pain, toothaches, sore throat pain, menstrual cramps, fever reduction, cold and flu symptoms, and post-surgical pain management. It is approved for OTC use and does not require a prescription for standard adult doses.
Acetaminophen works in the central nervous system by raising the body's pain threshold and reducing fever through action on the hypothalamus — the brain's temperature-regulation center. It does not inhibit prostaglandin synthesis in peripheral tissues the same way NSAIDs do, which is why it has minimal effect on inflammation but is very effective at blocking pain and lowering fever. It takes effect within 30–45 minutes.
Adults and children 12 and over: Take 2 tablets (1000mg) every 6 hours as needed. Do not take more than 4000mg (8 tablets) in 24 hours. Do not combine with other acetaminophen-containing products. Do not use for pain for more than 10 days or for fever for more than 3 days without medical advice. Liver damage may occur if you take more than directed.
Acetaminophen 500mg is suitable for adults and children 12 and older. It is often preferred for people with stomach sensitivity, kidney concerns, or those who cannot take NSAIDs. Not recommended for people with liver disease or heavy alcohol use. Consult your doctor before use if pregnant or breastfeeding.
Acetaminophen is generally very safe when taken as directed. Rare side effects include allergic reactions (rash, itching). The most serious risk is liver damage from overdose — never exceed the recommended dose or combine with alcohol. Avoid if you have liver disease or consume 3+ alcoholic drinks per day.
Promedic is a licensed US online pharmacy committed to providing FDA-approved OTC medications at competitive prices. We source all products from reputable US-licensed distributors and manufacturers. Every order is handled with discretion, packaged securely, and shipped to all 50 states. Our pharmacy team is available to answer any questions about Acetaminophen 500mg or any other products in our inventory. Order with confidence — quality and customer service are our top priorities.
Do I need a prescription to buy Acetaminophen 500mg?
No. Acetaminophen 500mg is an over-the-counter (OTC) medication available without a prescription for standard adult use.
How quickly will my order arrive?
We offer standard and expedited shipping to all 50 US states. Contact us for estimated delivery times to your location.
Is the generic version as effective as the brand name?
Yes. All OTC medications we carry must meet FDA quality and efficacy standards. Generic versions contain the same active ingredient at the same strength as their branded equivalents.
No. Unlike NSAIDs such as Ibuprofen, acetaminophen does not reduce inflammation. It works centrally to block pain signals and lower fever. For inflammatory conditions like arthritis, ibuprofen or naproxen may be more effective. See MedlinePlus: Acetaminophen.
The maximum recommended adult dose is 4,000mg (8 tablets of 500mg) per 24 hours. However, to reduce liver risk, many doctors recommend staying under 3,000mg/day. Never combine with other acetaminophen-containing products (e.g., NyQuil). Source: FDA — Acetaminophen and Liver Injury.
Yes — Ibuprofen and acetaminophen can generally be taken together since they work differently. This is sometimes used for better pain control. Consult your doctor before combining. Read: Ibuprofen 200mg Product Page.
You should avoid or limit alcohol while taking acetaminophen. Drinking 3 or more alcoholic beverages daily while taking acetaminophen significantly increases the risk of liver damage. Do not take acetaminophen if you have liver disease or heavy alcohol use.
Tylenol is a brand name; acetaminophen (also called paracetamol or APAP) is the generic active ingredient. Generic acetaminophen 500mg contains the exact same compound at the same dose as Tylenol Extra Strength, at a significantly lower cost.
Promedic is a US licensed pharmacy delivering genuine FDA-approved OTC medications to all 50 states. Secure ordering, discreet packaging, and competitive pricing.
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Healthcare Professional & Medical Reviewer, Promedic
Andrew Gaon is a healthcare professional and medical reviewer at Promedic, where he helps ensure that medical content is accurate, evidence-based, and easy for patients to understand. He reviews articles for clinical accuracy, current treatment guidelines, and patient safety, ensuring information meets high editorial and healthcare standards. Andrew is dedicated to providing reliable, trustworthy medical information that empowers patients to make informed healthcare decisions.