Naproxen 220mg tablets 100ct — long-lasting pain and inflammation relief

220mg tablets, 100-count bottle

Buy Naproxen Sodium 220mg (80ct) Online — 12-Hour OTC Pain & Inflammation Relief

Order FDA-Approved Naproxen 220mg — Fewer Doses, Longer Relief for Arthritis & Pain

Estimated: $9–13 per pack

220mg sodium tablets, 80-count bottle

Why Buy Naproxen 220mg from Promedic USA?

  • All-day relief with fewer doses — 1 tablet lasts up to 12 hours
  • Reduces pain, fever, AND inflammation
  • Ideal for arthritis and chronic pain conditions
  • Same ingredient as Aleve at lower cost
  • FDA-approved OTC formula
  • 80-count pack — great value for regular users
  • Proven in millions of patients worldwide

About Naproxen Sodium 220mg (80ct) — Complete Product Guide

Naproxen Sodium 220mg is an OTC nonsteroidal anti-inflammatory drug (NSAID) best known by the brand name Aleve. Unlike ibuprofen which requires dosing every 4–6 hours, naproxen offers extended 8–12 hour relief with just one tablet — making it ideal for conditions like arthritis, tendinitis, and chronic back pain where sustained relief throughout the day is essential.

What Conditions Does Naproxen 220mg Treat?

Naproxen 220mg is indicated for the relief of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, bursitis, gout flares, muscle aches and back pain, menstrual cramps, headache and migraine, fever reduction, and minor acute injuries. It is approved for OTC use and does not require a prescription for standard adult doses.

How Does Naproxen 220mg Work?

Like other NSAIDs, naproxen inhibits COX-1 and COX-2 enzymes to block prostaglandin production, reducing pain, fever, and inflammation. Its longer half-life compared to ibuprofen means the drug stays active in your system for 8–12 hours per dose. Onset of action typically occurs within 30–60 minutes, with peak pain relief at 1–2 hours.

Dosage and Usage Instructions

Adults and children 12 and over: Take 1 tablet (220mg) every 8 to 12 hours. If needed, a second tablet may be taken within the first hour. Do not exceed 2 tablets (440mg) in any 8–12 hour period or 3 tablets (660mg) in 24 hours. Take with food or milk to reduce stomach upset. Do not use for more than 10 days for pain or 3 days for fever without medical direction.

Key Benefits of Naproxen 220mg

  • All-day relief with fewer doses — 1 tablet lasts up to 12 hours
  • Reduces pain, fever, AND inflammation
  • Ideal for arthritis and chronic pain conditions
  • Same ingredient as Aleve at lower cost
  • FDA-approved OTC formula
  • 80-count pack — great value for regular users
  • Proven in millions of patients worldwide

Who Can Use Naproxen 220mg?

Suitable for adults and children 12+ for short-term OTC use. Avoid if you have stomach ulcers, kidney disease, heart disease, or take blood thinners. Elderly patients should use with caution due to increased GI risk. Not for use in late pregnancy. Always consult your doctor for chronic pain management.

Possible Side Effects

Common side effects include stomach upset, nausea, heartburn, and headache. Less common: dizziness, ringing in ears. Serious risks (rare with short-term OTC use): GI bleeding, kidney issues, cardiovascular effects. Take with food or antacids to reduce stomach irritation. Not recommended for long-term use without medical supervision.

Why Order Naproxen 220mg from Promedic?

Promedic is a licensed US online pharmacy committed to providing FDA-approved OTC medications at competitive prices. We source all products from reputable US-licensed distributors and manufacturers. Every order is handled with discretion, packaged securely, and shipped to all 50 states. Our pharmacy team is available to answer any questions about Naproxen 220mg or any other products in our inventory. Order with confidence — quality and customer service are our top priorities.

Frequently Asked Questions — Naproxen 220mg

Do I need a prescription to buy Naproxen 220mg?
No. Naproxen 220mg is an over-the-counter (OTC) medication available without a prescription for standard adult use.

How quickly will my order arrive?
We offer standard and expedited shipping to all 50 US states. Contact us for estimated delivery times to your location.

Is the generic version as effective as the brand name?
Yes. All OTC medications we carry must meet FDA quality and efficacy standards. Generic versions contain the same active ingredient at the same strength as their branded equivalents.

Frequently Asked Questions — Naproxen 220mg

How long does naproxen 220mg last?

Naproxen provides 8–12 hours of relief per dose — significantly longer than Ibuprofen (4–6 hours) or acetaminophen. This makes it ideal for chronic pain conditions like arthritis where consistent coverage is needed. Source: MedlinePlus: Naproxen.

Is naproxen stronger than ibuprofen?

Naproxen and Ibuprofen are both NSAIDs with similar effectiveness, but naproxen has a longer duration. Naproxen 220mg OTC is equivalent in strength to about 200–400mg of ibuprofen. For quick short-term relief, ibuprofen may act faster; for all-day coverage, naproxen is preferred.

Can I take naproxen every day?

For short-term use (under 10 days for pain, 3 days for fever), daily naproxen is generally safe for healthy adults. Long-term daily use increases risk of stomach ulcers, cardiovascular events, and kidney issues. Always consult a healthcare provider for chronic use. See FDA NSAID Safety Warning.

Who should not take naproxen?

Naproxen is not recommended if you have kidney disease, stomach ulcers, heart disease, or take blood thinners. Do not use in the third trimester of pregnancy. Not suitable for children under 12 without medical advice.

What is the difference between naproxen and Aleve?

Aleve is the brand name; naproxen sodium 220mg is the generic active ingredient. Generic naproxen 220mg is bioequivalent to Aleve and provides the same 8–12 hour relief at a lower cost.

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About the Medical Reviewer

Andrew Gaon - Medical Reviewer at Promedic

Andrew Gaon

Healthcare Professional & Medical Reviewer, Promedic

Andrew Gaon is a healthcare professional and medical reviewer at Promedic, where he helps ensure that medical content is accurate, evidence-based, and easy for patients to understand. He reviews articles for clinical accuracy, current treatment guidelines, and patient safety, ensuring information meets high editorial and healthcare standards. Andrew is dedicated to providing reliable, trustworthy medical information that empowers patients to make informed healthcare decisions.