Spedra (Avanafil): The Fastest-Acting ED Medication Reviewed

By Promedic Medical Team  |  July 17, 2026  |  8 min read

Spedra (avanafil) is the newest FDA-approved erectile dysfunction medication and arguably the most convenient. Where Viagra and Levitra require 30-60 minutes, Spedra can work in as little as 15 minutes. Here is a complete review.

Key Takeaway: Spedra has the fastest onset of any approved ED medication — 15-30 minutes — with a good safety profile and fewer food interactions. Excellent for men who want spontaneity without the planning required by older PDE5 inhibitors.

What is Spedra (Avanafil)?

Spedra contains avanafil and was FDA-approved in 2012. It is a fourth-generation PDE5 inhibitor with a more selective, faster-acting molecular structure than sildenafil or tadalafil. It comes in 50mg, 100mg, and 200mg tablets. Clinical trials reported in the Journal of Sexual Medicine showed onset in as little as 15 minutes in men with mild to moderate ED.

Speed Comparison: Spedra vs Other ED Medications

MedicationTypical OnsetDuration
Spedra (Avanafil)15-30 minutes6-8 hours
Levitra (Vardenafil)25-60 minutes4-6 hours
Viagra (Sildenafil)30-60 minutes4-6 hours
Kamagra Oral Jelly15-30 minutes4-6 hours
Cialis (Tadalafil)30-45 minutesUp to 36 hours

Food and Alcohol Interactions

Like Levitra, Spedra is minimally affected by food — a significant advantage over Viagra. You can take it with or without a meal. Moderate alcohol (1-2 drinks) is generally compatible, though heavy drinking should be avoided with any ED medication.

Side Effects

Avanafil shares common PDE5 inhibitor side effects (headache, flushing, nasal congestion) but clinical data suggests these are generally milder and less frequent than sildenafil, per the European Medicines Agency. Notably lower risk of vision changes (associated with sildenafil) and back pain (associated with tadalafil).

Who is Spedra Best For?

Try Spedra — The Fastest-Acting ED Medication

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About the Medical Reviewer

Andrew Gaon - Medical Reviewer at Promedic

Andrew Gaon

Healthcare Professional & Medical Reviewer, Promedic

Andrew Gaon is a healthcare professional and medical reviewer at Promedic, where he helps ensure that medical content is accurate, evidence-based, and easy for patients to understand. He reviews articles for clinical accuracy, current treatment guidelines, and patient safety, ensuring information meets high editorial and healthcare standards. Andrew is dedicated to providing reliable, trustworthy medical information that empowers patients to make informed healthcare decisions.